The key purpose of my role is to manage AstraZeneca’s environmental impact across all activities and products.  I strive to ensure that we maximise our resource efficiency, transition to using more renewable natural resources, embrace circular approaches to natural resource and waste management wherever possible, and ensure the environmental safety of our life changing medicines.  I have accountability for the delivery of our environmental protection ambitions, whether our Ambition Zero Carbon strategy, our water and waste reduction targets, our product environmental stewardship initiatives, and our scientific leadership in managing pharmaceuticals in the environment.

Sitting on the Global Sustainability Leadership 团队 and representing sustainability on the UK Leadership 团队, I have felt enormous pride seeing how sustainability considerations have really come to the forefront of AstraZeneca’s decision making and strategy for the future. It is an exciting place to be.

I joined AstraZeneca in 1995 as an experimental scientist to study the environmental fate, behaviour and degradation of pharmaceuticals as they enter the environment after patient use. I have always been passionate about science-based advocacy and my PhD in environmental microbiology and biochemistry from Cardiff University, which investigated the bacterial metabolism of nitrate esters that are used as active ingredients in cardiovascular drugs and explosives, set me up for my current role. Being at the science-policy interface to ensure regulations are based on sound science and that all stakeholders work together to ensure that patients can access medicines without compromising the health of our natural environment is an aspect of my role that I really enjoy.
 

I am passionate 关于 ensuring environmental protection throughout the whole of the 产品介绍 lifecycle of a pharmaceutical from discovery, development, 产品介绍ion and patient use, right through to end of life disposal. Our patients and society are increasing aware of the impacts that we are having on our planet and how that impacts our health. I want them to be reassured that AstraZeneca is committed to effectively managing the environmental risks of its activities and 产品介绍s to proactively minimise its environmental impact.

Jason Snape Global Head of Environmental Protection

The scientific leadership I provide through my science-based advocacy has been recognised through my appointments as an Honorary Clinical Professor at the University of Warwick and a Professor of Practice in environmental engineering at the University of Newcastle. I also chair the European pharmaceutical industries working group on the environmental risk assessment of human medicines and represent AstraZeneca at the AMR Industry Alliance Manufacturing and Environment working group.

Another aspect of my role that I really enjoy is working with academic centres of excellence through open innovation and strategic collaborations with groups such as the Innovative Medicines Initiate, the European Commission, the Natural Environment Research Council and Biotechnology and the Biological Sciences Research Council to help manage environmental concerns related to pharmaceutical 产品介绍ion and the presence of pharmaceuticals in the environment.  Emerging areas of study include the application of the latest artificial intelligence technologies to integrate predictive environmental impact assessments earlier in drug development and the environmental risks posed by increasing patient access to medicines in low- and middle-income countries that lack basic sanitation infrastructure.

I am passionate 关于 ensuring environmental protection throughout the whole of the 产品介绍 lifecycle of a pharmaceutical from discovery, development, 产品介绍ion and patient use, right through to end of life disposal.  Our patients and society are increasing aware of the impacts that we are having on our planet and how that impacts our health.  I want them to be reassured that AstraZeneca is committed to effectively managing the environmental risks of its activities and 产品介绍s to proactively minimise its environmental impact.


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Pharmacology beyond the patient: environmental risks of pharmaceutical use in Europelol外围投注网站

Lina Gunnarsson, Jason R. Snape, Bas Verbruggen, Stewart F. Owen, Erik Kristiansson, Luigi Margiotta-Casaluci, Tobias Österlund, Kathryn Hutchinson, Dean Leverett, Becky Marks, Charles R. Tyler, Environment International, Volume 129, 2019, Pages 320-332, ISSN 0160-4120.

https://doi.org/10.1016/j.envint.2019.04.075

Science‐based Targets for Antibiotics in Receiving Waters from Pharmaceutical Manufacturing Operationslol外围投注网站

Tell, J., Caldwell, D.J., Häner, A., Hellstern, J., Hoeger, B., Journel, R., Mastrocco, F., Ryan, J.J., Snape, J., Straub, J.O. and Vestel, J. (2019). Integr Environ Assess Manag, 15: 312-319.

https://doi.org/10.1002/ieam.4141

Characterising the occurrence of pharmaceuticals in the River Nairobi catchmentlol外围投注网站

Simone Bagnis, Alistair Boxall, Antony Gachanja, Mark Fitzsimons, Martin Murigi, Jason Snape, Alan Tappin, John Wilkinson, Sean Comber, Science of The Total Environment, Volume 703, 2020, 134925, ISSN 0048-9697.

https://doi.org/10.1016/j.scitotenv.2019.134925

Spatially Explicit Large-Scale Environmental Risk Assessment of Pharmaceuticals in Surface Water in Chinalol外围投注网站

Ying Zhu, Jason Snape, Kevin Jones, and Andrew Sweetman, Environmental Science & Technology 2019 53 (5), 2559-2569

DOI: 10.1021/acs.est.8b07054

Machine Learning for Environmental Toxicology: A Call for Integration and Innovationlol外围投注网站

Thomas H. Miller, Matteo D. Gallidabino, James I. MacRae, Christer Hogstrand, Nicolas R. Bury, Leon P. Barron, Jason R. Snape, and Stewart F. Owen, Environmental Science & Technology 2018 52 (22), 12953-12955

DOI: 10.1021/acs.est.8b05382

Critical knowledge gaps and research needs related to the environmental dimensions of antibiotic resistancelol外围投注网站

D.G. Joakim Larsson, Antoine Andremont, Johan Bengtsson-Palme, Kristian Koefoed Brandt, Ana Maria de Roda Husman, Patriq Fagerstedt, Jerker Fick, Carl-Fredrik Flach, William H. Gaze, Makoto Kuroda, Kristian Kvint, Ramanan Laxminarayan, Celia M. Manaia, Kaare Magne Nielsen, Laura Plant, Marie-Cécile Ploy, Carlos Segovia, Pascal Simonet, Kornelia Smalla, Jason Snape, Edward Topp, Arjon J. van Hengel, David W. Verner-Jeffreys, Marko P.J. Virta, Elizabeth M. Wellington, Ann-Sofie Wernersson, Environment International, 2018

https://doi.org/10.1016/j.envint.2018.04.041.

Application of prioritization approaches to optimize environmental monitoring and testing of pharmaceuticalslol外围投注网站

Emily E. Burns, Laura J. Carter, Jason Snape, Jane Thomas-Oates & Alistair B.A. Boxall (2018), Journal of Toxicology and Environmental Health, Part B, 21:3, 115-141, DOI: 10.1080/10937404.2018.1465873

Integrating human and environmental health in antibiotic risk assessment: A critical analysis of protection goals, species sensitivity and antimicrobial resistancelol外围投注网站

Gareth Le Page, Lina Gunnarsson, Jason Snape, Charles R. Tyler, Environment International, Volume 109, 2017, Pages 155-169, ISSN 0160-4120,

https://doi.org/10.1016/j.envint.2017.09.013.

ECOdrug: a database connecting drugs and conservation of their targets across specieslol外围投注网站

Bas Verbruggen, Lina Gunnarsson, Erik Kristiansson, Tobias Österlund, Stewart F Owen, Jason R Snape, Charles R Tyler, Nucleic Acids Research, Volume 46, Issue D1, 4 January 2018, Pages D930–D936, 

https://doi.org/10.1093/nar/gkx1024

Pharmaceuticals in soils of lower income countries: Physico-chemical fate and risks from wastewater irrigationlol外围投注网站

Katherine Lees, Mark Fitzsimons, Jason Snape, Alan Tappin, Sean Comber, Environment International, Volume 94, 2016, Pages 712-723, ISSN 0160-4120,

https://doi.org/10.1016/j.envint.2016.06.018.

Ecotoxicological assessment of antibiotics: A call for improved consideration of microorganismslol外围投注网站

Kristian K. Brandt, Alejandro Amézquita, Thomas Backhaus, Alistair Boxall, Anja Coors, Thomas Heberer, John R. Lawrence, James Lazorchak, Jens Schönfeld, Jason R. Snape, Yong-Guan Zhu, Edward Topp, Environment International, Volume 85, 2015, Pages 189-205, ISSN 0160-4120,

https://doi.org/10.1016/j.envint.2015.09.013.

Management Options for Reducing the Release of Antibiotics and Antibiotic Resistance Genes to the Environmentlol外围投注网站

Amy Pruden, D.G. Joakim Larsson, Alejandro Amézquita, Peter Collignon, Kristian K. Brandt, David W. Graham, James M. Lazorchak, Satoru Suzuki, Peter Silley, Jason R. Snape, Edward Topp, Tong Zhang, and Yong-Guan Zhu, Environmental Health Perspectives, Published:1 August 2013 

https://doi.org/10.1289/ehp.1206446

 

Human Health Risk Assessment (HHRA) for Environmental Development and Transfer of Antibiotic Resistancelol外围投注网站

Nicholas J. Ashbolt, Alejandro Amézquita, Thomas Backhaus, Peter Borriello, Kristian K. Brandt, Peter Collignon, Anja Coors, Rita Finley, William H. Gaze, Thomas Heberer, John R. Lawrence, D.G. Joakim Larsson, Scott A. McEwen, James J. Ryan, Jens Schönfeld, Peter Silley, Jason R. Snape, Christel Van den Eede, and Edward Topp, Environmental Health Perspectives, Published:1 September 2013

https://doi.org/10.1289/ehp.1206316

Implementing Ecopharmacovigilance in Practice: Challenges and Potential Opportunitieslol外围投注网站

Holm, G., Snape, J.R., Murray-Smith, R. et al. Drug Saf (2013) 36: 533. https://doi.org/10.1007/s40264-013-0049-3

Pharmaceuticals and Personal Care Products in the Environment: What Are the Big Questions?lol外围投注网站

Alistair B.A. Boxall, Murray A. Rudd, Bryan W. Brooks, Daniel J. Caldwell, Kyungho Choi, Silke Hickmann, Elizabeth Innes, Kim Ostapyk, Jane P. Staveley, Tim Verslycke, Gerald T. Ankley, Karen F. Beazley, Scott E. Belanger, Jason P. Berninger, Pedro Carriquiriborde, Anja Coors, Paul C. DeLeo, Scott D. Dyer, Jon F. Ericson, François Gagné, John P. Giesy, Todd Gouin, Lars Hallstrom, Maja V. Karlsson, D. G. Joakim Larsson, James M. Lazorchak, Frank Mastrocco, Alison McLaughlin, Mark E. McMaster, Roger D. Meyerhoff, Roberta Moore, Joanne L. Parrott, Jason R. Snape, Richard Murray-Smith, Mark R. Servos, Paul K. Sibley, Jürg Oliver Straub, Nora D. Szabo, Edward Topp, Gerald R. Tetreault, Vance L. Trudeau, and Glen Van Der Kraak, Environmental Health Perspectives, Published: 1 September 2012

https://doi.org/10.1289/ehp.1104477

Environmental risk assessment of human pharmaceuticals in the European Union: A case study with the β‐blocker atenolollol外围投注网站

Küster, A. , Alder, A. C., Escher, B. I., Duis, K. , Fenner, K. , Garric, J. , Hutchinson, T. H., Lapen, D. R., Péry, A. , Römbke, J. , Snape, J. , Ternes, T. , Topp, E. , Wehrhan, A. and Knacker, T. (2010), Environmental risk assessment of human pharmaceuticals in the European Union: A case study with the β‐blocker atenolol. Integr Environ Assess Manag, 6: 514-523.

https://doi.org/10.1897/IEAM_2009-050.1

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